456 Independent causal effect of psoriasis on multiple sclerosis identified by Mendelian randomization

Psoriasis and multiple sclerosis (MS) are physiologically distinct yet share genetic signals have overlapping pathogenesis. Previous studies suggest psoriasis patients at greater risk of MS than the general population, two diseases also comorbidities traits (for example, they both more prevalent in northern latitudes). To evaluate whether there is a direct causal relationship, we conducted Mendelian randomization (MR) analysis with six different techniques, using existing GWAS for (11,024 cases 16,336 controls) (14,802 26,703 controls); addressed 10 potential confounding exposures, previously suggested to be associated diseases, by including data from body mass index, coronary artery disease, inflammatory bowel disease (IBD), type 1 diabetes (T1D), 2 (T2D), asthma, rheumatoid arthritis, drinks per week, cigarettes day, vitamin D levels. Four MR techniques indicated significant effect on (FDR<0.05) showed nominal significance, whereas was not any analyses. When all covariates nominally least one technique multivariable analysis, still has (p=5.8×10-3, OR=1.04), independent T1D (p=4.3×10-7, OR=1.05), T2D (p=2.3×10-3, OR=1.08), IBD (p=1.6×10-11, OR=1.11) (p=9.4×10-3, OR=0.75) while BMI drinks/per week were significant. By applying traits, been able reveal most important modifiable factors determine indeed an relationship between MS.